Symbol
Name
ID

Tet2
tet methylcytosine dioxygenase 2
MGI:2443298

Phenotype annotations related to immune system

Darker colors indicate more annotations

Human Phenotypes	Acute myeloid leukemia	Subacute progressive viral hepatitis
Disease(s) Associated with TET2	Acute myeloid leukemia	Subacute progressive viral hepatitis
acute myeloid leukemia
hepatocellular carcinoma

Mouse Phenotypes

abnormal monocyte differentiation

increased DN1 thymic pro-T cell number

enlarged spleen

increased spleen weight

decreased pro-B cell number

increased double-negative T cell number

abnormal myelopoiesis

myeloid hyperplasia

increased neutrophil cell number

increased granulocyte number

decreased B cell number

decreased pre-B cell number

increased B cell number

increased monocyte cell number

increased leukocyte cell number

abnormal myeloid leukocyte morphology

abnormal spleen morphology

increased spleen red pulp amount

increased splenocyte number

liver inflammation

Availability

Mouse Genotype

Tet2^{Gt(AN0709)Wtsi}/Tet2^{Gt(AN0709)Wtsi}

Tet2^tm1.1Mjxu/Tet2^tm1.1Mjxu

Tet2^tm1.2Rao/Tet2^tm1.2Rao

Tet2^{Gt(AN0709)Wtsi}/Tet2⁺

Tet2^tm1.1Mjxu/Tet2⁺

Tet2^tm1.1Iaai/Tet2^tm1.1Iaai
Tg(Mx1-cre)1Cgn/0 (conditional)

Tet2^tm1.1Iaai/Tet2^tm1.1Iaai
Tg(VAV1-cre)1Graf/0 (conditional)

Tet2^tm1Ics/Tet2^tm1Ics
Tg(Mx1-cre)1Cgn/0 (conditional)

Tet2^tm1.1Iaai/Tet2⁺
Tg(VAV1-cre)1Graf/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23